---
product_id: 13572222
title: "Japanese Knotweed Natural Extract Tincture (Polygonum Cuspidatum)"
brand: "montana farmacy"
price: "₱2507"
currency: PHP
in_stock: true
reviews_count: 8
category: "Montana Farmacy"
url: https://www.desertcart.ph/products/13572222-japanese-knotweed-natural-extract-tincture-polygonum-cuspidatum
store_origin: PH
region: Philippines
---

# 67+ polyphenols blend 40 mg resveratrol per dose fast-acting inflammation relief Japanese Knotweed Natural Extract Tincture (Polygonum Cuspidatum)

**Brand:** montana farmacy
**Price:** ₱2507
**Availability:** ✅ In Stock

## Summary

> 🌿 Unlock nature’s secret weapon against inflammation and aging!

## Quick Answers

- **What is this?** Japanese Knotweed Natural Extract Tincture (Polygonum Cuspidatum) by montana farmacy
- **How much does it cost?** ₱2507 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.ph](https://www.desertcart.ph/products/13572222-japanese-knotweed-natural-extract-tincture-polygonum-cuspidatum)

## Best For

- montana farmacy enthusiasts

## Why This Product

- Trusted montana farmacy brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Powerful Polyphenol Complex:** Harnesses 67+ bioactive compounds for holistic wellness
- • **Sustainably Sourced & Organic:** Farm-friendly extraction ensures purity and ethical impact
- • **Multi-Dimensional Health Booster:** Supports cardiovascular, immune, skin, and joint health
- • **Rapid Inflammation & Pain Relief:** Topical application reduces joint swelling within minutes
- • **Clinically Supported Resveratrol Dose:** Delivers 40 mg daily to combat oxidative stress

## Overview

Japanese Knotweed Natural Extract Tincture is a potent herbal supplement rich in resveratrol and over 67 polyphenols, sourced sustainably and recommended by herbalist Stephen Buhner. Clinically shown to reduce oxidative stress and inflammation, it offers fast-acting relief for joint pain and supports cardiovascular and immune health. Trusted by users for its efficacy in managing rheumatoid arthritis symptoms and promoting overall wellness.

## Description

Japanese Knotweed Tincture As recommended by Stephen Buhner Our very own herbal Extracts made with plants and herbs from Farmer friendly/sustainable and organic sources. We carry some standards and also hard to find tinctures. ****The products and the information provided about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site, product labeling or packaging is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before before taking any medication or supplements, especially if you are pregnant or if you have or suspect you might have a health problem.

Review: Japanese Knotweed improves inflammation and oxidative stress. - Japanese knotweed (Polygonum cuspidatum) is an herb used in Traditional Chinese Medicine and contains resveratrol — a naturally occurring compound found in the skin of grapes and other plant sources, known for its antioxidant, anti-inflammation, heart-protective and immune-stimulating properties (1). While limited trials have been performed in humans, researchers believe Japanese Knotweed’s benefits are attributed to the presence of resveratrol. Over 67 polyphenols including quinones, stilbenes, flavonoids, coumarins and ligans have also been identified in Japanese Knotweed (2). With the help of future studies, researchers will be able to better understand how these compounds contribute to this herb’s pharmacological effects. Japanese knotweed improves inflammation and alleviates oxidative stress. Chronic inflammation is a contributing factor of age-related diseases and conditions such as diabetes, cardiovascular and autoimmune diseases (3). Inflammation and oxidative stress go hand-in-hand in that the inflammatory process induces oxidative stress, which in turn reduces the antioxidant defense system. The aim of a 2010 study was to evaluate the effect of a Polygonum cuspidatum extract on oxidative and inflammatory stress in overall healthy participants. Twenty adults were randomized to receive placebo or Polygonum cuspidatum extract containing 40 mg resveratrol daily for six weeks. At the end of the study, supplementation with the extract resulted in a significant reduction in all the testing parameters for oxidative and inflammatory stress (4). In another study, topical application of Polygonum cuspidatum extract inhibited the development of ear edema (swelling caused by the buildup of excess fluid in the body’s tissues) and inflammation in a mouse model (5). Japanese knotweed promotes cardiovascular health. The results of a systematic review and meta-analysis of randomized, controlled, clinical trials revealed that when taken in high doses, resveratrol had a cardioprotective effect specifically in people with diabetes. Dosages of ≥300 mg/day had a systolic blood pressure-lowering effect (6). Japanese knotweed can be a potential treatment for rheumatoid arthritis. An arthritis- and inflammation-induced animal model used in a recent study revealed the ability of ethyl acetate extract of Polygonum cuspidatum to reduce inflammation and alleviate pain. Researchers found the extract to be effective in providing pain relief in the animal hot plate test and tail-flick test at a dosage of 200 mg/kg. It did not, however, provide pain relief in the acetic acid-induced writhing test. To evaluate the extract’s ability to reduce inflammation, researchers relied on a serotonin-induced paw edema model and Freund’s complete adjuvant (FCA)-induced adjuvant arthritis model. It was found that the extract inhibited the swelling inflammatory response within 12 minutes after the serotonin injection, at both 100 and 200 mg/kg doses. In the FCA-induced adjuvant arthritis model, 100 mg/kg resulted in significantly suppressed joint swelling within five days, while 200 mg/kg of the extract showed the similar result within three days (7). These results are encouraging especially for rheumatoid arthritis sufferers who, among other symptoms, experience joint pain and swelling. Japanese knotweed may help speed the healing time of wounds. Polygonum cuspidatum extract has long been used in Traditional Chinese Medicine as a treatment to induce wound healing. In 2012, researchers set out to investigate its wound healing activity in a clinical setting using a rat study. Results showed that in comparison to the control group, wound healing rates in the group treated with topical Polygonum cuspidatum extract were significantly higher at three, seven, 14 and 21 days. In addition, microscopic studies revealed more well-organized bands of collagen, more fibroblasts and hair follicles and less inflammatory cells in the extract group (8). Japanese Knotweed is also being studied for its possible role as a skin lightening agent. Japanese knotweed helps to prevent the growth of human cancer cells. Results from in vitro and animal studies show resveratrol’s potential role in preventing and treating certain types of cancer (9). Researchers have found that resveratrol has an antitumor effect on neuroblastomas in mice; dose dependently inhibits the growth of estrogen receptor(ER)-positive MCF-7 cells (a breast cancer cell line used for clinical study); and induces human promyelocytic leukemia (HL-60) cell death. In addition, resveratrol or a combination of resveratrol and quercetin are effective inhibitors of oral squamous carcinoma cell (SCC-25) growth and proliferation (10,11,12). Japanese knotweed may help prevent flu viruses. In 2015, researchers tested the effects of over 300 traditional Chinese medicines on the replication of various influenza virus strains in a lung cell line. Impressively, of all the tested medicines, Polygonum cuspidatum and its active components, resveratrol and emodin, were found to effectively inhibit influenza virus replication, specifically the influenza A virus, including such strains as H1N1 (13). Japanese knotweed may help treat allergies. Researchers have found that emodin, an anthraquinone compound present in Japanese knotweed, has the potential to prevent and treat allergic reactions. Using an in vivo passive anaphylaxis animal model and in vitro mouse bone marrow-derived mast cells, researchers noted that emodin has the ability to suppress activation of mast cells and thereby the anaphylactic reaction (14).
Review: Knotweed has a job! We never knew! - Marvelous product! I have RA and apply it directly to the skin over my swollen joints. Within minutes the pain is reduced. It works better than any other application I have tried. I cannot take this supplement orally due to being on a blood thinner, Applying it cutaneously has had no effect on my coag times Severall months later: I am reordering as I am now off of anticoagulants. It is the absolute best counter inflammation extract I have used. Japanese Knotweek tincture with it hugely high concentration of resveratrol keeps the inflammation of my joints down to the point where I can walk, turn pages in books, reach to my back to pull clothes on, etc. It works better than any other product I have tried and I don't have to take pain killers when I take the tincture--my dose is 10-15 drops tid.

## Features

- As recommended by Stephen Buhner

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B00HNFH5S0 |
| Best Sellers Rank | #228,706 in Health & Household ( See Top 100 in Health & Household ) #1,016 in Single Homeopathic Remedies |
| Customer Reviews | 4.3 4.3 out of 5 stars (177) |
| Date First Available  | January 2, 2014 |
| Is Discontinued By Manufacturer  | No |
| Manufacturer  | Montana Farmacy |

## Product Details

- **Brand:** Montana Farmacy
- **Item Form:** liquid
- **Item Package Quantity:** 1
- **Manufacturer:** Montana Farmacy
- **Package Information:** Bottle

## Images

![Japanese Knotweed Natural Extract Tincture (Polygonum Cuspidatum) - Image 1](https://m.media-amazon.com/images/I/31IRMRPem0L.jpg)
![Japanese Knotweed Natural Extract Tincture (Polygonum Cuspidatum) - Image 2](https://m.media-amazon.com/images/I/71PmyYoLZyL.jpg)

## Questions & Answers

**Q: How many ounces is this?**
A: (1) One

**Q: I received a bottle of Japanese Knotweed tincture (Montana Pharmacy) today, but there were no dosage instructions.  Can anyone help?**
A: Dear Marilyn, I had the same question when I received the same product and the answer that the Montana Pharmacy gave me was "ask the prescribing health care provider"; which I could not do so, I researched the issue and basically found recommendations for a range of drops from 5-15 two to three times per day. What I decided to do was take 15 drops twice a day and that worked for me. My Best - Dana

**Q: Why would there be no dosage instructions with this product? What  is the typical dosage? I saw 1 response but not sure if its accurate. Anyone?**
A: I take a dropperful 2x daily

**Q: how many drops are in 0.7 ML looks like it would be on the lable.**
A: there are approx 1000 DROPS in a 1 ounce bottle.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Japanese Knotweed improves inflammation and oxidative stress.
*by D***5 on December 29, 2014*

Japanese knotweed (Polygonum cuspidatum) is an herb used in Traditional Chinese Medicine and contains resveratrol — a naturally occurring compound found in the skin of grapes and other plant sources, known for its antioxidant, anti-inflammation, heart-protective and immune-stimulating properties (1). While limited trials have been performed in humans, researchers believe Japanese Knotweed’s benefits are attributed to the presence of resveratrol. Over 67 polyphenols including quinones, stilbenes, flavonoids, coumarins and ligans have also been identified in Japanese Knotweed (2). With the help of future studies, researchers will be able to better understand how these compounds contribute to this herb’s pharmacological effects. Japanese knotweed improves inflammation and alleviates oxidative stress. Chronic inflammation is a contributing factor of age-related diseases and conditions such as diabetes, cardiovascular and autoimmune diseases (3). Inflammation and oxidative stress go hand-in-hand in that the inflammatory process induces oxidative stress, which in turn reduces the antioxidant defense system. The aim of a 2010 study was to evaluate the effect of a Polygonum cuspidatum extract on oxidative and inflammatory stress in overall healthy participants. Twenty adults were randomized to receive placebo or Polygonum cuspidatum extract containing 40 mg resveratrol daily for six weeks. At the end of the study, supplementation with the extract resulted in a significant reduction in all the testing parameters for oxidative and inflammatory stress (4). In another study, topical application of Polygonum cuspidatum extract inhibited the development of ear edema (swelling caused by the buildup of excess fluid in the body’s tissues) and inflammation in a mouse model (5). Japanese knotweed promotes cardiovascular health. The results of a systematic review and meta-analysis of randomized, controlled, clinical trials revealed that when taken in high doses, resveratrol had a cardioprotective effect specifically in people with diabetes. Dosages of ≥300 mg/day had a systolic blood pressure-lowering effect (6). Japanese knotweed can be a potential treatment for rheumatoid arthritis. An arthritis- and inflammation-induced animal model used in a recent study revealed the ability of ethyl acetate extract of Polygonum cuspidatum to reduce inflammation and alleviate pain. Researchers found the extract to be effective in providing pain relief in the animal hot plate test and tail-flick test at a dosage of 200 mg/kg. It did not, however, provide pain relief in the acetic acid-induced writhing test. To evaluate the extract’s ability to reduce inflammation, researchers relied on a serotonin-induced paw edema model and Freund’s complete adjuvant (FCA)-induced adjuvant arthritis model. It was found that the extract inhibited the swelling inflammatory response within 12 minutes after the serotonin injection, at both 100 and 200 mg/kg doses. In the FCA-induced adjuvant arthritis model, 100 mg/kg resulted in significantly suppressed joint swelling within five days, while 200 mg/kg of the extract showed the similar result within three days (7). These results are encouraging especially for rheumatoid arthritis sufferers who, among other symptoms, experience joint pain and swelling. Japanese knotweed may help speed the healing time of wounds. Polygonum cuspidatum extract has long been used in Traditional Chinese Medicine as a treatment to induce wound healing. In 2012, researchers set out to investigate its wound healing activity in a clinical setting using a rat study. Results showed that in comparison to the control group, wound healing rates in the group treated with topical Polygonum cuspidatum extract were significantly higher at three, seven, 14 and 21 days. In addition, microscopic studies revealed more well-organized bands of collagen, more fibroblasts and hair follicles and less inflammatory cells in the extract group (8). Japanese Knotweed is also being studied for its possible role as a skin lightening agent. Japanese knotweed helps to prevent the growth of human cancer cells. Results from in vitro and animal studies show resveratrol’s potential role in preventing and treating certain types of cancer (9). Researchers have found that resveratrol has an antitumor effect on neuroblastomas in mice; dose dependently inhibits the growth of estrogen receptor(ER)-positive MCF-7 cells (a breast cancer cell line used for clinical study); and induces human promyelocytic leukemia (HL-60) cell death. In addition, resveratrol or a combination of resveratrol and quercetin are effective inhibitors of oral squamous carcinoma cell (SCC-25) growth and proliferation (10,11,12). Japanese knotweed may help prevent flu viruses. In 2015, researchers tested the effects of over 300 traditional Chinese medicines on the replication of various influenza virus strains in a lung cell line. Impressively, of all the tested medicines, Polygonum cuspidatum and its active components, resveratrol and emodin, were found to effectively inhibit influenza virus replication, specifically the influenza A virus, including such strains as H1N1 (13). Japanese knotweed may help treat allergies. Researchers have found that emodin, an anthraquinone compound present in Japanese knotweed, has the potential to prevent and treat allergic reactions. Using an in vivo passive anaphylaxis animal model and in vitro mouse bone marrow-derived mast cells, researchers noted that emodin has the ability to suppress activation of mast cells and thereby the anaphylactic reaction (14).

### ⭐⭐⭐⭐⭐ Knotweed has a job! We never knew!
*by G***M on November 2, 2017*

Marvelous product! I have RA and apply it directly to the skin over my swollen joints. Within minutes the pain is reduced. It works better than any other application I have tried. I cannot take this supplement orally due to being on a blood thinner, Applying it cutaneously has had no effect on my coag times Severall months later: I am reordering as I am now off of anticoagulants. It is the absolute best counter inflammation extract I have used. Japanese Knotweek tincture with it hugely high concentration of resveratrol keeps the inflammation of my joints down to the point where I can walk, turn pages in books, reach to my back to pull clothes on, etc. It works better than any other product I have tried and I don't have to take pain killers when I take the tincture--my dose is 10-15 drops tid.

### ⭐⭐⭐⭐⭐ Great product I take it for Lyme disease part of ...
*by A***S on November 11, 2016*

Great product I take it for Lyme disease part of an herbal protocol and I notice when I don't take it. I'm not achey not as fatigued and I'm kept even keeled. I've bought a cheaper version from another company and right away you could see that the cheaper one was watered down., and I became achey , tired and sick again as if not taking anything . So this product from this company "Montana farmacy" is top notch quality and I will continue to buy from them again and again. Ty!

## Frequently Bought Together

- Japanese Knotweed Natural Extract Tincture (Polygonum Cuspidatum)
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*Product available on Desertcart Philippines*
*Store origin: PH*
*Last updated: 2026-01-24*