---
product_id: 16887578
title: "Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings"
brand: "jarrow formulas"
price: "₱7786"
currency: PHP
in_stock: true
reviews_count: 11
category: "Jarrow Formulas"
url: https://www.desertcart.ph/products/16887578-jarrow-formulas-same-supplement-400-mg-60-tablets-high-concentration
store_origin: PH
region: Philippines
---

# Vegan & allergen-free formula 400 mg potent SAMe dose Enteric-coated for max bioavailability Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings

**Brand:** jarrow formulas
**Price:** ₱7786
**Availability:** ✅ In Stock

## Summary

> 💡 Elevate your wellness game with Jarrow’s premium SAMe — because your body deserves the best!

## Quick Answers

- **What is this?** Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings by jarrow formulas
- **How much does it cost?** ₱7786 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.ph](https://www.desertcart.ph/products/16887578-jarrow-formulas-same-supplement-400-mg-60-tablets-high-concentration)

## Best For

- jarrow formulas enthusiasts

## Why This Product

- Trusted jarrow formulas brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Advanced Enteric Coating:** Ensures SAMe survives stomach acid for superior absorption and bioactivity.
- • **Mood & Cognitive Balance:** Supports balanced mood and brain metabolism, empowering you to stay sharp and stress-resilient.
- • **Vegan & Allergy-Friendly:** Free from gluten, soy, dairy, nuts, and more—perfect for clean, conscious lifestyles.
- • **Clinically Potent 400 mg Dose:** Delivers a high concentration of active S,S-SAMe for effective joint, liver, and brain support.
- • **60-Day Supply for Consistent Wellness:** One tablet daily keeps your joints, liver, and mind in peak condition without interruption.

## Overview

Jarrow Formulas SAMe Supplement delivers a potent 400 mg dose of naturally derived S,S-SAMe in an enteric-coated tablet, designed to support joint health, liver function, brain metabolism, and balanced mood. This vegan, allergen-free formula offers 60 servings per bottle, ensuring a full two months of consistent, high-quality supplementation for professionals seeking holistic, science-backed wellness.

## Description

Jarrow Formulas SAM-e provides S-Adenosyl Methionine, a naturally derived compound that plays a role in supporting multiple biochemical systems in the body.(1) Each tablet supplies 400 mg of SAM-e to help maintain joint health and liver function.(1) As a joint support supplement, it fits easily into the daily routine of any health-conscious individual interested in overall wellness.(1) The vegan, non-GMO tablets do not contain gluten, wheat, soy, dairy, egg, fish/shellfish, peanut/nut or sesame, so they suit those with dietary restrictions. Whether used as a stand alone supplement at home or taken with a multivitamin, adults simply consume one easy to swallow tablet by mouth with water on an empty stomach, or as directed by a qualified healthcare professional. Jarrow Formulas continues its original mission to design superior dietary supplements that empower people in their quest for healthy living and a tailored wellness regimen. (1) These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Review: I am so amazed with this product - I have used desertcart for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!
Review: Better than an anti-depressant. - For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit. SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief. I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available. Within a week of taking SAM-e, I could function. Things were looking up. I was me again. That was two summers ago and would not be without it since. Here's the kicker: I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited. MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12." I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose. I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price. --Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.

## Features

- High Concentration of Active S,S Form: the biologically active form of SAMe uses the S,S structure; the fermentation without chemical solvents preserves 68-80% of Sam-e 400mg, the highest level available
- Joint Health, Liver Function and Antioxidant Defense: SAMe 400mg supports the production of healthy connective tissue; plus, SAM e 400mg metabolism supports the synthesis of glutathione, critical for antioxidant defenses and liver functions (1)
- Brain Metabolism and Mood: SAM-e supplement's methylation reactions are involved in the synthesis of phosphatidylcholine and neurotransmitters such as dopamine, norepinephrine, and serotonin; SAMe supports a balanced mood (1)
- Enteric Coating: SAMe supplement is a metabolite of methionine, provides 400 mg from 800 mg SAMe tosylate disulfate and is manufactured under low temperature, enteric-coated to ensure a biologically active product
- Superior Nutrition and Formulation: Jarrow Formulas aims to promote optimal health with effective, affordable vitamins and supplements; customers are assured of purity and value

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00V3M9CYY |
| Age Range Description | Adult |
| Best Sellers Rank | #22,452 in Health & Household ( See Top 100 in Health & Household ) #739 in Blended Vitamin & Mineral Supplements #1,791 in Sales & Deals |
| Brand | Jarrow Formulas |
| Brand Name | Jarrow Formulas |
| Color | 60 Count |
| Container Type | Bottle |
| Customer Reviews | 4.3 out of 5 stars 1,326 Reviews |
| Diet Type | Vegan, Vegetarian |
| Dosage Form | 400 mg |
| Flavor | Unflavored |
| Global Trade Identification Number | 00790011200420 |
| Item Dimensions | 1.75 x 3.25 x 6 inches |
| Item Form | Tablet |
| Item Weight | 3.36 ounces |
| Manufacturer | Jarrow Formulas |
| Manufacturer Part Number | SAM460 |
| Material Features | Gluten Free |
| Model Name | SAMe 400 |
| Model Number | SAM460 |
| Number of Items | 1 |
| Primary Supplement Type | Vitamin |
| Product Benefits | Bone & Joint Support, Stress Relief |
| Special Ingredients | Amino Acid |
| Total Servings Per Container | 60 |
| UPC | 790011200420 784922636478 |
| Unit Count | 60 Count |

## Product Details

- **Brand:** Jarrow Formulas
- **Diet Type:** Vegan, Vegetarian
- **Flavor:** Unflavored
- **Item Form:** Tablet
- **Item Weight:** 0.21 Pounds
- **Item dimensions L x W x H:** 1.75 x 3.25 x 6 inches
- **Primary Supplement Type:** Vitamin
- **Product Benefits:** Bone & Joint Support, Stress Relief
- **Special Ingredients:** Amino Acid
- **Unit Count:** 60 Count

## Images

![Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings - Image 1](https://m.media-amazon.com/images/I/71LmfirQxxL.jpg)
![Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings - Image 2](https://m.media-amazon.com/images/I/71VYA4VGlpL.jpg)
![Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings - Image 3](https://m.media-amazon.com/images/I/71NObxeKsCL.jpg)
![Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings - Image 4](https://m.media-amazon.com/images/I/81ubVVcLUVL.jpg)
![Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings - Image 5](https://m.media-amazon.com/images/I/71JRd3j5ZPL.jpg)

## Available Options

This product comes in different **Size** options.

## Customer Reviews

### ⭐⭐⭐⭐⭐ I am so amazed with this product
*by W***0 on October 23, 2015*

I have used Amazon for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!

### ⭐⭐⭐⭐⭐ Better than an anti-depressant.
*by O***A on September 23, 2013*

For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit. SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief. I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available. Within a week of taking SAM-e, I could function. Things were looking up. I was me again. That was two summers ago and would not be without it since. Here's the kicker: I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited. MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12." I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose. I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price. --Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.

### ⭐⭐⭐⭐⭐ Never Disappointed -Buy Quality and Follow Directions
*by R***E on October 5, 2011*

Ever since a vet recommended this product for a geriatric dog, I've used it for numerous elder dogs since then. It is also wonderful presurgery (check with your surgeon of course) and after any kind of stress or recovery. I was a Foster home for a breed rescue for many years and this is part of my arsenal to help dogs get part transition stress. To me, seeing the clear results in dogs negates any thought of a placebo effect. Plus, it's backed by enough peer reviewed studies that vets at least prescribe it with confidence.Not this brand,but I have taken care to ensure that the brand I use matches the $80(!) Prescription quality precisely. Narrow is the one I trust the most, but there are other brands which are also excellent. What you want is: Made in USA. Even from some of our friends I suspect the potency, and from China you may as well plant them in the ground like magic beans. No offense to individuals from China, but supplements sourced from those manufacturers are consistently lacking in actual active ingredient. :( Enteric coating. The active ingredient is absorbed in the colon, so must pass the stomach. It will also give you a massive belly ache! Blister packaging or some other way to seal the tablets individually. The active ingredient is highly volatile. It is sensitive to light, oxygen, heat, and moisture. Also, you want to avoid scratching or chipping the coating. The directions say take on an empty stomach and wait thirty minutes before food. The minute you wake up is the best time. Nothing should be down there triggering extra digestive action. All this is totally worth it. I have three dogs, one twelve,one thirteen, one eighteen. The twelve and thirteen year older still play Frisbee, I mean really play, like jumping and stuff. The eighteen years old still requires her daily walks and training time,or she gets into trouble, countersurfing or removing the kitchen trash from the LOCKED cabinet. The only other thing I do for them in terms of supplements is melatonin at night to ensure correct sleep patterns.

## Frequently Bought Together

- Jarrow Formulas SAMe 400 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To a 60 Day Supply
- Jarrow Formulas® SAMe 200 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To A 60 Day Supply
- Jarrow Formulas Magnesium L-Threonate, MagMind Magtein Brain Supplements for Memory Support, 90 Veggie Capsules, Up to a 30 Day Supply

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*Product available on Desertcart Philippines*
*Store origin: PH*
*Last updated: 2026-05-29*