Turmeric Curcumin Complex with Black Pepper Extract - 755mg per Capsule, 180 Veg. Caps - Contains Piperine (for Superior Absorption and Tumeric Bio-Availability) and 95% Standardized Curcuminoids

Turmeric (Curcumin) The Most Clinical Studied Herb of all Herbs in the world, December 28, 2014By E J ClarkClinical Trials[...]Also Search: [...]M.D. Anderson Cancer Center In HustonTurmeric Search: [...]Please note that this website is purely for information purpose. Although FDA has approved curcumin as “generally regarded as safe (GRAS)”, none of these claims have been approved by the FDA. Although 40 different clinical trials have been completed, most of the evidence about the activity of curcumin is still based on preclinical studies.turmeric An East Indian plant that is a member of the ginger family and is used as a spice and food color. The underground stems are used in some cultures to treat certain stomach problems.The substance in turmeric that gives it a yellow color (curcumin) is being studied in the treatment of cancer, Alzheimer’s disease, cystic fibrosis and psoriasis. The scientific name is Curcuma longa. Also called Indian saffron and jiang huang.Turmeric Search: [...]Completed clinical trials with CurcuminThe Most Clinical Studied Herb of all Herbs in the worldDisease Dose/Frequency PatientsPhase 1 2000 mg/day 10Phase-I 500-12,000 mg/day x 90 days 25Phase 1 500-12,000 mg/day 24Rheumatoid arthritis 1,200 mg/day x 14 days 18Postoperative inflammation 500 mg/day; 3 x/day x 5 days 46External cancerous lesions 1% ointment x several months 62Cardiovascular 500 mg/day x 7 days 10Atherosclerosis 10 mg; 2 x/day x 28 days 12HIV 625 mg; 4 x/day x 56 days 40Gall bladder function 20 mg, single dose (2h) 12Gall bladder function 20-80 mg, single dose (2h) 12Chronic anterior uveitis 375 mg; 3 x/day x 84 days 32Idiopathic Inflamm Orbital pseudotumors 375 mg; 3 x/day x 180-660 days 8Psoriasis 1% curcumin gel 40Psoriasis 4.5 g/day x 84 days 18Colorectal cancer 36-180 mg/day x 120 days 15Colorectal cancer 500-3700 mg/day x 120 days 15Irritable bowel syndrome 72-144 mg/day x 56 days 207Liver metastasis of CRC 500-3700 mg/day x 7 days 12Colorectal cancer 500-3700 mg/day x 7 days 12Cadaveric renal transplantation 480 mg; x 1-2/day x 30 days 43Tropical pancreatitis 500 mg/day x 42 days 20Ulcerative proctitis 550 mg; x 2-3/day x 60 days 5Crohn's disease 360 mg; x 3/day x 30 days 5Ulcerative colitis 2000 mg/day x 180 days 89Familial adenomatous polyposis 480 mg; x 3/day x 180 days 5Cognitive function - 1010Prostatic intra-epithelial neoplasia (PIN) - 24Helicobacter pylori infection 300 mg/day x 7 days 25Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic.Biochem Pharmacol. 2008 Feb 15;75(4):787-809.________________________________________Ongoing clinical trials with CurcuminDisease Study Type/Design Patients # Trial SiteColorectal cancer, ACF Phase-I, Randomized - Rockefeller University HospitalColon cancer, ACF Phase-III, Randomized 100 Tel-Aviv Sourasky Med. CenterColorectal cancer, ACF Phase-II, Non-randomized 48 University of Illinois, ChicagoFAP Phase-II, Randomized 68 University of PennsylvaniaFAP Phase-II, Non-randomized - Johns Hopkins UniversityAberrant crypt foci Prevention, Randomized 60 Cancer Institute of New JerseyPancreatic cancer Phase-II, Non-randomized 45 Rambam Medical Center, HaifaPancreatic cancer Phase-II, Non-randomized 50 M.D. Anderson Cancer CenterPharmacokinetics Treatment, Non-randomized 6 Massachusetts General HospitalMyelodysplactic syndrome Phase-II 30 Univ. Massachusetts, WorcesterAlzheimer's disease Phase-II, Randomized 33 Univ. of California Los AngelesAlzheimer's disease Phase-I & II, Randomized7 30 Chinese University of HKMultiple myeloma Randomized 30 M.D. Anderson Cancer CenterMyelodysplastic syndrome Phase-I & II, Non-randomized 50 Hadassah Medical OrganizationPsoriasis Phase II, Non-randomized - University of PennsylvaniaEpilepsy Phase 1 ? AIIMS, Delhi, India (Gupta YK)Advanced HNSCC Phase II (1-8 g/day; 56 days) 40 Himalyan Institute Med. Sci.HNSCC Phase II/III DBRPC 300 AIIMS, DelhiCervical cancer (Stage IIb, IIIb) Phase II/III DBRPC 100 AIIMS, DelhiOral premalignant lesions Phase II/III DBRPC 90 Tata Memorial Cancer CtrOral premalignant lesions Phase II/III DBRPC 96 Amrita Institute, KeralaOral leukoplakia Phase II (curcumin gel) 100 Reg. cancer center, KeralaGall bladder cancer Phase II (2-8 g/day) 60 BHU, varanasiPancreatic cancer Phase II (8 g/day) 40 Kyoto UniversityPSC Phase I (8 g/day) 20 Amsterdam Medical Ctr.Ulcerative colitis Phase I (8 g/day) 20 Amsterdam Medical Ctr.Barretts Metaplasia Phase I (8 g/day) 20 Amsterdam Medical Ctr.MGUS Phase I (3.4 g/day) St. George Hospital, SydneyGoel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic.Biochem Pharmacol. 2008 Feb 15;75(4):787-809.Prevention and treatment of neurodegenerative diseases by curcuminAggarwal et al, in Micronutrients and Brain Health (ed. by Packer L, Helmut Sies H, Eggersdorfer M, and Enrique Cadenas E, CRC, Press, 2008)Introduction[...]Although science has led to remarkable additions to our repertoire of drugs, it is estimated that 80% of the World population cannot afford the current treatment for their diseases. For many modern medicines their benefits are outweighed by their toxic side effects. Thus treatments that are safer, more effective, and cheaper are needed. The mechanisms of action of traditional medicines are shrouded in mystery, even though they have been used for thousand of years: neither the active components nor their molecular targets have been very well identified. Curcumin, a yellow component of turmeric or curry powder, however, is an exception. Almost 2000 papers have been published on the subject. Its mechanism of action can be compared to inhibitors of cyclooxygenase-2 (Celebrex), HER2 (Herceptin), TNF (Enbrel, Humira, Remicade), EGFR (Erbitux and Iressa), and vascular endothelial cell growth factor (Avastin), all of which have been approved for human use by the FDA. There is one big difference, however: curcumin as a single agent can down regulate every one of these targets, making it more likely to be effective against the targeted disease. Thus curcumin regulates multiple targets (multitargeted therapy) and is inexpensive. Centuries of use as a dietary agent have demonstrated its safety; as an added reassurance, human clinical trials of curcumin have shown it to be safe. For further proof of concept, please follow the journey on this website.Curcumin is an active component of turmeric (Curcuma longa), used as a spice and as an Ayurvedic medicine for centuries on the Indian subcontinent. Curcumin has been shown to suppress carcinogenesis of the skin, liver, lung, colon, stomach, and breast. It has also been shown to inhibit the proliferation of a wide variety of tumor cells in culture and promote apoptosis through Bid cleavage, cytochrome C release, caspase-9 activation and then caspase-3 activation. Curcumin has been shown to lower blood cholesterol, promote wound healing, prevent skin wrinkling, inhibit inflammation, suppress rheumatoid arthritis, and inhibit human immunodeficiency virus replication. Curcumin mediates this wide variety of therapeutic effects through the regulation of the transcription factors nuclear factor-kappa B and activator protein, suppression of IκBα kinase and c-jun N-terminal kinase, and inhibition of expression of cyclooxygenase 2, cyclinD1, adhesion molecules, matrix metalloproteases, inducible nitric oxide synthase, HER2, epithelial growth factor receptor, bcl-2, bcl-xl, and tumor necrosis factor. Pharmacologically, curcumin is quite safe, and doses as high as 8 g/day have been administered orally to humans with no side effects. Numerous therapeutic activities as outlined above, its pharmacological safety and its color qualifies curcumin as “Indian solid gold"What is Curcumin?[...]CONCLUSIONS: We conclude that curcumin is well tolerated and our preliminary results suggest biologic activity in pancreatic cancer.[...]curcumin in tumericTurmeric Adds Spice to Your HealthBy Cancerwise Blogger on January 31, 2011 9:57 AM | Comments (5)By Lana Maciel, MD Anderson Staff WriterOne of the keys to tumor suppression could possibly lie in the Indian spice turmeric. Often used in curry dishes, it is commonly known as "Indian solid gold" for its proven health benefits.Various scientific studies have shown that the yellow compound in turmeric, curcumin, contains potent antioxidant and anti-inflammatory properties. These can inhibit tumor cell growth and suppress enzymes that activate carcinogens.In fact, a small Phase II study at MD Anderson in 2008 indicated that in patients with pancreatic cancer, daily dosage of curcumin without chemotherapy helped slow tumor growth in some patients and reduced the size of a tumor in one patient.Bharat Aggarwal, Ph.D., professor in the Department of Experimental Therapeutics, continues to conduct and analyze a number of studies that focus on the effects of curcumin on cancer. He says he believes it is effective on all forms of the disease due to its suppression of angiogenesis (blood vessel growth) of tumor cells."No cancer has been found, to my knowledge, which is not affected by curcumin," Aggarwal says. "The reason curcumin is so effective against cancer is that it hits not just a single target or cell signaling pathway but dozens of targets implicated in cancer."In addition to these scientific findings, the cancer rate in South Asia makes an even stronger case for the cancer-fighting benefits of turmeric. It is used regularly in culinary dishes of this region."The incidence of the top four cancers in the United States-- colon, breast, prostate and lung -- is 10 times lower in India," Aggarwal says.Incorporate turmeric into your daily dietUsed as a primary ingredient in many Indian, Persian, Thai and Malay dishes, turmeric pairs well with garlic, citrus, coriander and cumin. You, too, can reap the benefits of this spice by using it in your daily cooking.For starters, try the following recipe, courtesy of Aggarwal, as a great side dish for a healthy curried chicken dish.Vegetables With TurmericIngredients:• 3 tablespoons olive oil• 1 teaspoon turmeric• ¼ teaspoon red chili powder• ½ teaspoon salt• ½ teaspoon cumin• ½ teaspoon coriander powder• ½ teaspoon pomegranate seeds• ½ teaspoon mango powder• Sliced vegetables such as potatoes, cauliflower, carrots, etc.• Sliced onions, ginger and tomatoesDirections:1. In a small bowl, mix together salt, turmeric, red chili, cumin and coriander powders.2. On a stovetop, heat the olive oil in a pan. First roast onions and ginger and then add vegetables and spice mix together in the pan and stir until vegetables are coated in spices.3. Allow vegetables to simmer on low heat for 10-15 minutes, stirring occasionally.4. Turn off the heat, sprinkle with sliced tomatoes, pomegranate seeds and mango powder and enjoy.Categories:• Cancer Prevention,• Cancer Research,• NutritionTags:• Cancerwise Feature StoryShareThis5 CommentsLola | January 31, 2011 11:31 AM | ReplyThe percentage of the active compound curcumin in tumeric is quite low. Curcumin has extremely limited bioavailability-- given the low amount of the active compound curcumin in tumeric, why would eating it be healthful?No scientist who actually understands statistics would confuse correlation with causality per statement "In addition to these scientific findings, the cancer rate in South Asia makes an even stronger case for the cancer-fighting benefits of turmeric. It is used regularly in culinary dishes of this region."The incidence of the top four cancers in the United States-- colon, breast, prostate and lung -- is 10 times lower in India," Aggarwal says."For interesting reading on curcumin for cancer, please see: [...] | February 2, 2011 4:27 PM | ReplyI've been taking curcumin capsules for more than 3 years, hoping to make a difference in the growth of my non-small cell lung cancer with bone metastases. The fact that I'm alive 4 years after diagnosis should suggest that something is helping; in addition I am walking 4 to 5 km (2 1/2 to 3 miles) a day, in less than an hour.Turmeric itself seems to contain an anti-fatigue factor, which was a totally unexpected benefit in the early days when I started swallowing a teaspoonful twice a day. Suddenly I had plenty of energy and could do things again. I've had the same reports from people with systemic mastocytosis, rheumatoid arthritis, and other diseases. For some people it makes no difference, but no harm trying it!

I was first introduced to the supplement Turmeric (and thus it's most active constituent Curcumin) through a tennis pro who advised that I take this product to reduce inflammation and encourage healing in an injured knee (torn meniscus). She gave me her partially full bottle for me to get started. After a about three weeks, I noticed a marked relief in pain (I'm on my feet a lot at my job). I was impressed! What impressed me further was when I went on the internet to research this supplement and discovered the "laundry list" of significant benefits that have been found! Turmeric with concentrated Curcumin has very powerful anti-oxidant and anti-inflammatory benefits that heals tissue damage as well as improve the function of many organs of the body. The anti-cancer, anti-heart disease, anti-arthritis, anti-alzheimer's... properties certainly grab one's attention! Read up on the product to find out more.When it was time for me to get a new bottle of the supplement, I chose this Vita-Breeze brand. Why? Well I kind of pride myself on being a good "quality & value finder". The VitaBreeze brand of Turmeric Curcumin: (1) contains more active ingredient for the dollar than most other competitors, (2) it's standardized to a very high degree of active ingredient, (3) it include the ingredient "piperine" which increases digestive absorption something like 10 times over!, (4) has been produced and inspected under GMP quality assurance standards, and finally (5) has more pills / milligrams per bottle, for the dollar, than most other competitors (AKA: VitaBreeze was the best value that I could find, by far).BTW, I shared this info with the tennis pro who had introduced me to Turmeric originally. She has since switched over to this brand! Thanks for reading my review.Jon G.

It's expensive but it's better than the local brands that offer curcumin and better trust a brand from the the states, even if it's more expensive here purely because I think they have stringent quality checks and they take lawsuits and getting sued pretty seriously.