---
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title: "Principles of Neural Science, Fifth Edition"
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# Principles of Neural Science, Fifth Edition

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Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated: the definitive neuroscience resource--from Eric R. Kandel, MD (winner of the Nobel Prize in 2000); James H. Schwartz, MD, PhD; Thomas M. Jessell, PhD; Steven A. Siegelbaum, PhD; and A. J. Hudspeth, PhD A Doody's Core Title for 2020! 900 full-color illustrations Deciphering the link between the human brain and behavior has always been one of the most intriguing--and often challenging--aspects of scientific endeavor. The sequencing of the human genome, and advances in molecular biology, have illuminated the pathogenesis of many neurological diseases and have propelled our knowledge of how the brain controls behavior. To grasp the wider implications of these developments and gain a fundamental understanding of this dynamic, fast-moving field, Principles of Neuroscience stands alone as the most authoritative and indispensible resource of its kind. In this classic text, prominent researchers in the field expertly survey the entire spectrum of neural science, giving an up-to-date, unparalleled view of the discipline for anyone who studies brain and mind. Here, in one remarkable volume, is the current state of neural science knowledge--ranging from molecules and cells, to anatomic structures and systems, to the senses and cognitive functions--all supported by more than 900 precise, full-color illustrations. In addition to clarifying complex topics, the book also benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. Principles of Neural Science then proceeds with an in-depth examination of the molecular and cellular biology of nerve cells, synaptic transmission, and the neural basis of cognition. The remaining sections illuminate how cells, molecules, and systems give us sight, hearing, touch, movement, thought, learning, memories, and emotions. The new fifth edition of Principles of Neural Science is thoroughly updated to reflect the tremendous amount of research, and the very latest clinical perspectives, that have significantly transformed the field within the last decade. Ultimately, Principles of Neural Science affirms that all behavior is an expression of neural activity, and that the future of clinical neurology and psychiatry hinges on the progress of neural science. Far exceeding the scope and scholarship of similar texts, this unmatched guide offers a commanding, scientifically rigorous perspective on the molecular mechanisms of neural function and disease--one that you'll continually rely on to advance your comprehension of brain, mind, and behavior. FEATURES The cornerstone reference in the field of neuroscience that explains how the nerves, brain, and mind function Clear emphasis on how behavior can be examined through the electrical activity of both individual neurons and systems of nerve cells Current focus on molecular biology as a tool for probing the pathogenesis of many neurological diseases, including muscular dystrophy, Huntington disease, and certain forms of Alzheimer's disease More than 900 engaging full-color illustrations--including line drawings, radiographs, micrographs, and medical photographs clarify often-complex neuroscience concepts Outstanding section on the development and emergence of behavior, including important coverage of

Review: Magnifique! - This is a massive volume that provides a detailed sense of "the principles of neural science," the work's title. Basic statistics: the book weighs about nine pounds; it is 1709 pages long; it has 67 chapters; there are six appendices; 79 authors are involved; the book is divided up into 9 parts, each with numerous chapters. To compare, the fourth edition (published in 2000) had about 1400 pages. This volume is not meant for a general audience, but it is a wonderful resource for those who can work their way through its many chapters. I have found earlier volumes in this series very helpful for one part of my academic research agenda (the political implications of human biology). Let's take a look at the structure of the volume, to illustrate the substance of the book. Part I provides an overall perspective on the scope of the book. The chapters examine the role of the brain in behavior, a summary of nerve cells and their function, and the relationship between genes, the brain, and behavior. With this serving as an introduction, Part II goes on to examine cells and the molecular biology of the neuron. Among subjects covered: The structure and nature of neurons and glial cells (which support neurons) and the electrical properties of neurons. Part III focuses on synapses, which provide for communication between and among neurons. How do synapses operate? What are chemical and electrical modes of operation? What is the role of neurotransmitters? Finally, this section considers diseases of the nerve and systems that they support. Part IV is very important for my research interests--"The Neural Basis of Cognition." How does the brain and its structure affect cognition Chapter 15 describes the structure of the central nervous system and how the cerebral cortex, for example, affects cognition. In the chapter is a discussion of how the cerebral cortex is organized by layers AND by columns. Other important chapters in this section include effects on cognitive functioning of the brain outside the cerebral cortex and how functional imaging of cognition works (and the limitations with the use of such technology). Part V summarizes our understanding of perception, how we come to experience the world around us. Subjects? The somatosensory system, touch, pain, vision (with five chapters devoted to the subject), the inner ear, hearing, and smell and taste. Part VI? Movement. The chapters herein explore the various elements in making movement possible. We learn of the different brain areas and other support systems underlying movement and locomotion. How do people process information? Part VII concentrates on this, and this segment is also of relevance for my own research interests. Part VIII targets development and emergence of behavior. The one chapter in this section that is most poignant to me is Chapter 59--"The Aging Brain." The chapter speaks to what we know of the effects of aging on the brain and its functioning. Finally, section IX, "Language, Affect, and Learning." These represent key issues of interest in our understanding of central features of being human. This book is not something that most of us would skim. But it is a compendium that well illustrates what we know about the structure and function of the brain. For those interested in the subject, this is an important work.
Review: Masterpiece for Neural Science studies - I am a urologist specializing in neurologically impaired patients so I read Kandels newest edition once they become available. This edition is superb with colorful and easily understood illustrations, diagrams and radiology studies including PET scans. The print is very legible and the spacing is perfect. It took a month to read the 1700 pages but its the best book i have read these last 10 years with Bruce Alberts Molecular Biology of the Cell whose 6th edition should be out later this year. I really found the molecular biology and anatomy chapter the perfect reintroduction for me. It provided me with the perfect detail and understanding for a paper I am writing on Strokes and their Effect on the Bladder. The disease specific Chapters on Stroke, Parkinsons, Multiple Sclerosis each are well detailed but with excellent explanations of the principles necessary for the clinician to get a strong hold on this relevant material. These chapters should be standard reading for all medical students and residents. The radiological studies chosen to illustrate these disease entities are the best i have seen and explain what is important to know and understand for each type of stroke, progressive MS or non progressive MS. I purchased it early after its release new for 70 dollars so with its success it will soon be a classic at 100 plus dollars and will still be worth every penny. I will now use this to teach my students the fundamentals of a neurological exam and to emphasis the commonly seen neurological disease seen by urologists. Thank you Dr Kandel for a book well worth the 7 year wait.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| Best Sellers Rank | #609,748 in Books ( See Top 100 in Books ) #98 in Neurosurgery (Books) #170 in Neuroscience (Books) #244 in Occupational Therapy (Books) |
| Customer Reviews | 4.8 out of 5 stars 535 Reviews |

## Images

![Principles of Neural Science, Fifth Edition - Image 1](https://m.media-amazon.com/images/I/61HdWqp4vGL.jpg)

## Customer Reviews

### ⭐⭐⭐⭐⭐ Magnifique!
*by S***N on April 14, 2013*

This is a massive volume that provides a detailed sense of "the principles of neural science," the work's title. Basic statistics: the book weighs about nine pounds; it is 1709 pages long; it has 67 chapters; there are six appendices; 79 authors are involved; the book is divided up into 9 parts, each with numerous chapters. To compare, the fourth edition (published in 2000) had about 1400 pages. This volume is not meant for a general audience, but it is a wonderful resource for those who can work their way through its many chapters. I have found earlier volumes in this series very helpful for one part of my academic research agenda (the political implications of human biology). Let's take a look at the structure of the volume, to illustrate the substance of the book. Part I provides an overall perspective on the scope of the book. The chapters examine the role of the brain in behavior, a summary of nerve cells and their function, and the relationship between genes, the brain, and behavior. With this serving as an introduction, Part II goes on to examine cells and the molecular biology of the neuron. Among subjects covered: The structure and nature of neurons and glial cells (which support neurons) and the electrical properties of neurons. Part III focuses on synapses, which provide for communication between and among neurons. How do synapses operate? What are chemical and electrical modes of operation? What is the role of neurotransmitters? Finally, this section considers diseases of the nerve and systems that they support. Part IV is very important for my research interests--"The Neural Basis of Cognition." How does the brain and its structure affect cognition Chapter 15 describes the structure of the central nervous system and how the cerebral cortex, for example, affects cognition. In the chapter is a discussion of how the cerebral cortex is organized by layers AND by columns. Other important chapters in this section include effects on cognitive functioning of the brain outside the cerebral cortex and how functional imaging of cognition works (and the limitations with the use of such technology). Part V summarizes our understanding of perception, how we come to experience the world around us. Subjects? The somatosensory system, touch, pain, vision (with five chapters devoted to the subject), the inner ear, hearing, and smell and taste. Part VI? Movement. The chapters herein explore the various elements in making movement possible. We learn of the different brain areas and other support systems underlying movement and locomotion. How do people process information? Part VII concentrates on this, and this segment is also of relevance for my own research interests. Part VIII targets development and emergence of behavior. The one chapter in this section that is most poignant to me is Chapter 59--"The Aging Brain." The chapter speaks to what we know of the effects of aging on the brain and its functioning. Finally, section IX, "Language, Affect, and Learning." These represent key issues of interest in our understanding of central features of being human. This book is not something that most of us would skim. But it is a compendium that well illustrates what we know about the structure and function of the brain. For those interested in the subject, this is an important work.

### ⭐⭐⭐⭐⭐ Masterpiece for Neural Science studies
*by S***D on May 25, 2013*

I am a urologist specializing in neurologically impaired patients so I read Kandels newest edition once they become available. This edition is superb with colorful and easily understood illustrations, diagrams and radiology studies including PET scans. The print is very legible and the spacing is perfect. It took a month to read the 1700 pages but its the best book i have read these last 10 years with Bruce Alberts Molecular Biology of the Cell whose 6th edition should be out later this year. I really found the molecular biology and anatomy chapter the perfect reintroduction for me. It provided me with the perfect detail and understanding for a paper I am writing on Strokes and their Effect on the Bladder. The disease specific Chapters on Stroke, Parkinsons, Multiple Sclerosis each are well detailed but with excellent explanations of the principles necessary for the clinician to get a strong hold on this relevant material. These chapters should be standard reading for all medical students and residents. The radiological studies chosen to illustrate these disease entities are the best i have seen and explain what is important to know and understand for each type of stroke, progressive MS or non progressive MS. I purchased it early after its release new for 70 dollars so with its success it will soon be a classic at 100 plus dollars and will still be worth every penny. I will now use this to teach my students the fundamentals of a neurological exam and to emphasis the commonly seen neurological disease seen by urologists. Thank you Dr Kandel for a book well worth the 7 year wait.

### ⭐⭐⭐⭐⭐ Wealth of Knowledge and Awesome Diagrams
*by S***S on February 19, 2016*

Wealth of Knowledge and Awesome Diagrams The book Principles of Neural Science by Kandel et. al. has been a fantastic compliment to the class I’m currently enrolled in at Iowa State. The immense amount of knowledge contained in the book enhances my learning and has helped to develop my understanding of neural science. The diagrams in the book are well illustrated and display the contents of the book effectively. This is a required book for graduation in my discipline and is for advanced learners only. The subject matter within the book might be difficult to grasp without some prior knowledge of neural science. The information in this book is outstanding and is unlike any other neural science textbook that I have read during my college career. With that said, the book is very “heavy”, in both weight and content. I haven’t weighed it myself, but it is the heaviest textbook I have had in my four years of college. However, with the relevant amount of information in the book, it is a price I’m willing to pay! I would recommend this textbook for people seeking an advanced education in the field of neural science. The book has complicated information, but with the detailed diagrams and case studies provided, the reader gains a better understanding of neural science.

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*Last updated: 2026-07-18*