Isdinceutics Retinal Advanced - Rejuvenating Facial Night Serum with Retinaldehyde and Melatonin 1.7 FL OZ (50 ml)

I’ve never used retinal/retinol etc, so using this product is my very first attempt. I am 40+, fair skin, sensitive skin, dry skin, med/large pores, still prone to hormonal breakouts, some sun damage freckling, pretty deep 11s, and very minor wrinkles anywhere else. I started using this right around 2/1/24. It’s now 2 months of almost nightly use since (I’ve skipped a couple nights here or there just from schedule issues). I do use a full 2 pumps each time, every night, and I run the excess down my neck and upper chest to help with signs of aging there. I thought FOR SURE I would have bad peeling, redness, etc because I have sensitive skin and usually EVERYTHING makes me red or break out. But this hansy been bad at all! I started to think that might mean it’s a dud product, but I have been going thru “purge” for about 3-4 weeks. Not constant, but a couple of rounds of very agitated pimples. Moreso than I usually get, and I am used to have them every month with my cycle. So that makes me feel like it’s doing SOMETHING! I think I may be on the downward slope of the purge…. Hopefully. How does my skin feel or look? Well, it actually does feel more hydrated and softer than ever. I love that! It looks slightly more even tone (between the breakout areas when I’m having pimples and generally all over when I’m not having a breakout.) I also feel like I’m seeing a little more radiance or glow. Nothing miraculous, but just a little more shine and luster. I have not noticed a reduction in my deep 11s or my 2 very fine forehead lines. So far I’m happy. It’s such an expensive product I hate that you have to spend so much to find out if it works, but I feel like the signs I’m seeing now support continued use and expense. At 2 months, it looks to me like I might have 1 month of product left in the jar. For the price I paid, if it lasts 3 months, that’s about $62 a month ($744 a year!). I’ve never had an rx from a derm, so I’m not sure how that compares to prescription and office visit costs. I’m going to continue trying this for the full year. If I feel confident that I’m seeing results, I’ll do a cost comparison of actually getting on and maintaining a retinoid rx or just continuing this product. Will update!

The best product!! Have been using for 9 months and have seen a significant improvement. My skin is more glowing and have seen a decrease in dark spots. Worth the price

Looooooove what this ISDIN retinol does to my skin. I purchased it originally from a pharmacy overseas as a recommendation from the pharmacist. I wanted to have smoother skin. I purchased it again off Amazon when I ran out. Great product! Just a pea size amount at night and moisturizer afterwards.

La piel mejora desde el primer día . Me mejoró las líneas de expresión y la apariencia de la piel .

I've been using ISDIN's Retinal Advanced serum for a few weeks now, and I'm genuinely impressed with how it's working for my skin. The formula feels luxurious and absorbs quickly without leaving any greasy residue. I have sensitive skin, and I was worried about irritation (since this contains retinaldehyde), but it's been surprisingly gentle—no peeling, redness, or dryness. I’ve noticed a more even tone and a slight softening of fine lines, especially around my eyes and mouth. The added melatonin is a nice touch—I don’t know if it’s doing anything directly, but it makes me feel like I’m supporting my skin’s nighttime repair. My only reason for giving 4 instead of 5 stars is the price. While the product works well, it is a bit expensive compared to others with similar ingredients. Still, the quality and effectiveness make it worth considering if you're looking for a high-end night serum that delivers results without being harsh.

La mejor inversión que he hecho en mi skincare, mi piel cambió mucho desde las primeras aplicaciones, lo amo no me arrepiento de haberlo comprado, por supuesto que voy a comprar otro cuando se me termine

The absolute best! I’ve used every high end product, and this is the holy grail!

I have been using Retinal Advanced for about 6 months. It is wonderful. The fine lines on my face are barely noticable now. I couldn't believe it when I first saw the difference. It has worked better than anything I have tried thus far! I highly recommend this product!