Can this be played in a classroom group?

I designed it specifically for my classroom, so yes absolutely. I would suggest starting out by just using the 8 cards in a player's hand, and don't use the Action Tiles, remove the Transition Metal, the Polyatomic Ions and Radioactive Cards. Simply deal 8 cards to each player, and flip two goal cards faceup (3 if playing 5 or more players) and then that's it. Once students get the hang of it, then you can add those other components in. Also, the game will play up to 7 players per copy of the game. However, sometimes having 7 students at a single table can get crowded and rambunctious. I usually played with 4 or 5 students to a game. Hope that helps!

Can 2 play easily? Do the rules differ for two-player play?

2 will work, however 3 or 4 is much better.

What ages is this appropriate for?

We recommend 8 years and up but this age range is dependent on the players familiarization with traditional games and/or chemistry. It's not a really tough game to learn especially if there's an adult to teach the game and help walk younger players through the first few play throughs. You can also find a great How to Play video here: https://www.youtube.com/watch?v=iCNNJqWCzL8

How does this compare to Compounded?

I don't know anything about the Compounded game, but this one is very hard to play. I reread the rules several times and couldn't follow the instructions on how to play and I'm a chemistry teacher! I didn't even try it out on my classes.

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Batteries Required?	No
Batteries Included	No
Material Type(s)	紙
Target Gender	Unisex
Manufacturer reference	GOT10032E
Product Dimensions	17.78 x 13.46 x 4.01 cm; 396.89 g
ASIN	B0B9DSMDMY

Ion: A Compound Building Game (2nd Edition) | A Chemistry Card Game for Kids, Teachers, Classrooms, Homeschool | Board

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